For a while, we’ve heard that Assassin’s Creed III will take place during the American Revolution. Considering Ezio’s story is done, this seems as possible as anything else. To further support these claims, it would seem a BestBuy employee emailed Kotaku some interesting details.
The first is a possible picture of the main character (see below), which has various elements that support the American Revolution talk. The other is that the game will be formally revealed on March 5th. While you should take this all with a grain of salt, this would definitely be an interesting direction for the series.