A new patch for Dead Nation was released last night and apparently, the patch has problems that somehow reset the campaign’s progress.
Here’s an official statement of Housemarquee from their official Facebook Page:
We are investigating a possible save game problem which occurs after patch v1.06 which was released last night. We have received reports that in some cases the patch resets the campaign progress. In the meantime please do not update if you are worried about losing your campaign progress.
While Housemarquee is investigating the problem, please make sure to deny the patch prompt when starting the game. Not updating to the newest patch might not allow you to play online.